Structure of PDB 5t2a Chain l Binding Site BS03

Receptor Information

>5t2a Chain l (length=81) Species: 5661 (Leishmania donovani)

TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFKTPK

Ligand information

>5t2a Chain C (length=162)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagc
aaagugcgauaagugguaucaauugcagaaucauuaauugcccaaucuuu
gaacgcaaacggcgcaugggagaagcucgagccauccccgugcaugccac
aucucagugucg

.........................................<<<<<<.((
.....>>>.....<<<<<......))............>>>>.>...>>>
....<<.....>><<<<<<<....<<<..>>>....>>>>>>>.......
............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5t2a Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): R20 R21 G23 A42 R44 T59 T61 G62 R63 C64 Y66 R72 R73 N76 H77 K79 T80 P81
• Binding residue (residue number reindexed from 1): R19 R20 G22 A41 R43 T58 T60 G61 R62 C63 Y65 R71 R72 N75 H76 K78 T79 P80

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:5t2a, PDBe:5t2a, PDBj:5t2a
• PDBsum: 5t2a
• PubMed: 27752045
• UniProt: P62885|RL37_LEIDO Large ribosomal subunit protein eL37 (Gene Name=RPL37)