Structure of PDB 8cvm Chain f Binding Site BS03

Receptor Information
>8cvm Chain f (length=203) Species: 1747 (Cutibacterium acnes) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHEMPRLKKQYREQIRAAMQEEFGYRNPMLIPGLEKIVVNMGVGDAAHDS
KVMDGAIRDITAITGQKPQVTKARKSIAQFKLREGQPIGCHVTLRGDRMW
EFADRLLTLALPRIRDFRGLNSNQFDGKGNYTFGLSEQVMFLEIDQDKID
RIRGMDITFVTTAQTNEEGKALLKHLGFPFKAKDDPKKAKTKRGPAYYAK
KKK
Ligand information
>8cvm Chain C (length=76) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgggguggagcagccugguagcucgucgggcucauaacccgaaggucgu
cgguucaaauccggcccccgcaacca
<<<<<<..<<<<.........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>.....
Receptor-Ligand Complex Structure
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PDB8cvm Sarecycline inhibits protein translation in Cutibacterium acnes 70S ribosome using a two-site mechanism.
Resolution2.66 Å
Binding residue
(original residue number in PDB)		I83 A84 R89
Binding residue
(residue number reindexed from 1)		I77 A78 R83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Biological Process
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Cellular Component
External links
PDB RCSB:8cvm, PDBe:8cvm, PDBj:8cvm
PDBsum8cvm
PubMed36864821
UniProtQ6A6N8|RL5_CUTAK Large ribosomal subunit protein uL5 (Gene Name=rplE)

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