Structure of PDB 6j6g Chain c Binding Site BS03

Receptor Information
>6j6g Chain c (length=436) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KGGVWTNVEDQILKAAVQKYGTHQWSKVASLLQKKTARQSELRWNEYLNP
KLNFTEFSKEEDAQLLDLARELPNQWRTIADMMARPAQVCVERYNRLLES
EDSEDEEKEMLAEARARLLNTQGKKATRKIRERMLEESKRIAELQKRREL
KQAGINVAIKKPKKKYGTDIDYNEDIVYEQAPMPGIYDTSTEDRQIKKKF
EQFERKVNRKGLLTPKELLPHDSGQEDNERSNIKSGKQLKSRIRKFFASL
PSPKNDFEILSEDEKEEDAEIAEYEKEEDNFIEPPSQDAPRVSLVAVPLA
YSTLKNNPQSAIDNKYNLLVANAINKEPHMESRMQHITQGRTSMKIQFKT
AMPPTEVLLESIQSKVESIEQLQRKLQHVQPLEQQNNEMCSTLCHHSLPA
LIEGQRKYYADYYAYRQEIRSLEGRRKRLQAMLNSS
Ligand information
>6j6g Chain L (length=208) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acgaaucucuuugccuuuuggcuuagaucaaguguaguaucuguucuuuu
cauguaacaacuaaugaccucagaggcucaauuuguuacaauacacauuu
uuuggcacccaaaauaggacgggaagagacuuuuaaagugagacgucgcg
acccucgcaggagucguucuugacuuuuuggucgcuugauguuucucucu
ucccguuc
..................................................
..<<<<<<<<.....<.<<<<.>>>>.>....>>>>>>>>..........
.................<<<<<<<<<<.<<<<<.>>>>><<<<<<<<<<<
<.<<......<<<<<<....>>>>>>...>>>>>>..>>>>>>>>..>>>
>>>>>>>.
Receptor-Ligand Complex Structure
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PDB6j6g Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H31 S34
Binding residue
(residue number reindexed from 1)		H23 S26
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000386 second spliceosomal transesterification activity
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0000350 generation of catalytic spliceosome for second transesterification step
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000974 Prp19 complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0071006 U2-type catalytic step 1 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j6g, PDBe:6j6g, PDBj:6j6g
PDBsum6j6g
PubMed30879786
UniProtQ03654|CEF1_YEAST Pre-mRNA-splicing factor CEF1 (Gene Name=CEF1)

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