Structure of PDB 6q2r Chain Y Binding Site BS03

Receptor Information

>6q2r Chain Y (length=572) Species: 9606 (Homo sapiens)

LYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRT
RLHENNWICIQEDTGLLYLNRSLDHSSWEKLSVRNHGFPLLTVYLKVFLS
CQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENRPPGTFH
QFRLLPVQFLCPNISVAYRLLGLPFRCAPDSLEVSTRWALDREQREKYEL
VAVCTVHEEVVMVPFPVTVYDEDDSAPTFPAGVDTASAVVEFKRKEDTVV
ATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQAN
GSFVRATVHDYRLVLNRNLSISENRTMQLAVLVNDSGVLLLHFNVSVLPV
SLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQL
LVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKG
ITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPR
GIKAGYGTCNCFPEEEKCFCEP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6q2r Chain Y Residue 2003

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6q2r Cryo-EM analyses reveal the common mechanism and diversification in the activation of RET by different ligands.
• Resolution: 4.3 Å
• Binding residue (original residue number in PDB): D266 S268 D300 D302 Y314 D378
• Binding residue (residue number reindexed from 1): D223 S225 D257 D259 Y271 D335
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6q2r, PDBe:6q2r, PDBj:6q2r
• PDBsum: 6q2r
• PubMed: 31535977
• UniProt: P07949|RET_HUMAN Proto-oncogene tyrosine-protein kinase receptor Ret (Gene Name=RET)