Structure of PDB 8qbt Chain W Binding Site BS03

Receptor Information
>8qbt Chain W (length=84) Species: 679895 (Escherichia coli BW25113) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHKKAGGSTRNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANV
GCGRDHTLFAKADGKVKFEVKGPKNRKFISIEAE
Ligand information
>8qbt Chain 6 (length=77) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcgaguagcgcagcuugguagcgcaacugguuugggaccagugggucg
gagguucgaauccucucucgccgacca
<<<<<<<..<<<<.........>>>>.<<<<<<.....>>>>>>.....<
<<<<.......>>>>>>>>>>>>....
Receptor-Ligand Complex Structure
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PDB8qbt Novel arrest peptides induce ribosome stalling by short circuiting the ribosomal peptidyltransferase activity
Resolution2.2 Å
Binding residue
(original residue number in PDB)		A2 K5 A6 G8
Binding residue
(residue number reindexed from 1)		A1 K4 A5 G7
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0043022 ribosome binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0001558 regulation of cell growth
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042256 cytosolic ribosome assembly
GO:0090070 positive regulation of ribosome biogenesis
GO:1902626 assembly of large subunit precursor of preribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8qbt, PDBe:8qbt, PDBj:8qbt
PDBsum8qbt
PubMed38503735
UniProtP0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)

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