Structure of PDB 8ceo Chain W Binding Site BS03

Receptor Information
>8ceo Chain W (length=304) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRPIDDIVKNLLKFVVRGFYGGSFVLVLDAILFHSVLAEDDLKQLLSINK
TELGPLIARLRSDRLISIHKQREYPPNSKSVERVYYYVKYPHAIDAIKWK
VHQVVQRLKDDLDKNSEPNGYMCPICLTKYTQLEAVQLLNFDRTEFLCSL
CDEPLVEDDSGKKNKEKQDKLNRLMDQIQPIIDSLKKIDDSRIEENTFEI
ALARLIPPQNQSHAAYTYNPKKGSTMATLHINITTASDEVAQRELQERQA
EEKRKQNAVPEWHKQSTIGKTALGREERENEKTLNDYYAALAKKQALEDE
FEDV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8ceo Chain W Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ceo Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		C124 C127 C149 C152
Binding residue
(residue number reindexed from 1)		C123 C126 C148 C151
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000993 RNA polymerase II complex binding
GO:0001097 TFIIH-class transcription factor complex binding
GO:0003697 single-stranded DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001113 transcription open complex formation at RNA polymerase II promoter
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005673 transcription factor TFIIE complex
GO:0005739 mitochondrion
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ceo, PDBe:8ceo, PDBj:8ceo
PDBsum8ceo
PubMed37014863
UniProtP36100|T2EA_YEAST Transcription initiation factor IIE subunit alpha (Gene Name=TFA1)

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