Structure of PDB 2j37 Chain W Binding Site BS03

Receptor Information
>2j37 Chain W (length=479) Species: 9616 (Canis sp.) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVK
SAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGNVIMFVGL
QGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPF
YGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVA
NAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGA
LSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNE
LKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDF
MSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARG
SGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLN
QQMAKMMDPRVLHHMGGMAGLQSMMRQFQ
Ligand information
>2j37 Chain Z (length=280) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cugcaaaguacccucagaagggaggcgaaauagagcacagcgauagucgg
gugagaaccccgacggccuaauggauaaggguuccucagcacugcugauc
agcugaggguuagccgguccuaagucauaccgcaacucgacuaugacgaa
augggaaacggguuaauauucccgugccacggggucgaucacgcugggca
ucgcccagucgaaccguccaacuccguggaagccguaauggcaggaagcg
gacgaacggcggcauagggaaacgugauuc
...........<<<.....>>>.......................<<<<<
<.......>>>>>>...................<<<<<<...<<.....>
>.>>>>>>....<<...<<<...<<<<<<.<<.....>>..>>>>>>...
..>>>..<<<<<........>>>>>>>.........<<<<<<<<<<<<<.
..>>>>>>><...<<<<<....<<<<<....<<<<...>>>>.....>>>
>>.....>>>>>....>......>>>>>>.
Receptor-Ligand Complex Structure
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PDB2j37 Following the signal sequence from ribosomal tunnel exit to signal recognition particle.
Resolution8.7 Å
Binding residue
(original residue number in PDB)		A393 K394 S397 Q488
Binding residue
(residue number reindexed from 1)		A384 K385 S388 Q479
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0019003 GDP binding
GO:0030942 endoplasmic reticulum signal peptide binding
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0030593 neutrophil chemotaxis
GO:0030851 granulocyte differentiation
GO:0031017 exocrine pancreas development
GO:0045047 protein targeting to ER
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2j37, PDBe:2j37, PDBj:2j37
PDBsum2j37
PubMed17086193
UniProtP61010|SRP54_CANLF Signal recognition particle subunit SRP54 (Gene Name=SRP54)

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