Structure of PDB 8qbk Chain U Binding Site BS03

Receptor Information
>8qbk Chain U (length=309) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAEYLNTFRLRNLGLPVMNNLHDMSKATRISVETLRLLIYTADFRYRIYT
VEKKGPEKRMRTIYQPSRELKALQGWVLRNILDKLSSSPFSIGFEKHQSI
LNNATPHIGANFILNIDLEDFFPSLTANKVFGVFHSLGYNRLISSVLTKI
CCYKNLLPQGAPSSPKLANLICSKLDYRIQGYAGSRGLIYTRYADDLTLS
AQSMKKVVKARDFLFSIIPSEGLVINSKKTCISGPRSQRKVTGLVISQEK
VGIGREKYKEIRAKIHHIFCGKSSEIEHVRGWLSFILSVDSKSHRRLITY
ISKLEKKYG
Ligand information
>8qbk Chain W (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugcgcacccuuagcgagaggccucuggauguugcggcauccugcauugaa
ucugaguuacu
...............<<<<..>>>><<<<<<<..>>>>>>>.........
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8qbk Retron-Eco1 assembles NAD + -hydrolyzing filaments that provide immunity against bacteriophages.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		K56 R63 I65 K73 R81 F96 E97 H99 Q100 Q161 G162 A163 P164 P167 M206 K231 C233 I234 S235 G236 P237 R238 S239 Q240 V247 S249 R257 E258 K261 R264 G283 S286 S290 R298
Binding residue
(residue number reindexed from 1)		K54 R61 I63 K71 R79 F94 E95 H97 Q98 Q159 G160 A161 P162 P165 M204 K229 C231 I232 S233 G234 P235 R236 S237 Q238 V245 S247 R255 E256 K259 R262 G281 S284 S288 R296
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006974 DNA damage response
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8qbk, PDBe:8qbk, PDBj:8qbk
PDBsum8qbk
PubMed38788717
UniProtP23070|RT86_ECOLX Retron Ec86 reverse transcriptase (Gene Name=ret)

[Back to BioLiP]