Structure of PDB 8a5y Chain U Binding Site BS03

Receptor Information
>8a5y Chain U (length=114) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKVKINEVHSVFAWSWHIPSDEDVCGICRASYNGTCPSCKFPGDQCPLVI
GLCHHNFHDHCIYRWLDTPTSKGLCPMCRQTFQLQKGLAINDAHVQKFVE
IVSRRREEMIEEGV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8a5y Chain U Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8a5y Cryo-EM structure of the S. cerevisiae APC/C-Cdh1 complex and comparison to apo unphosphorylated and phosphorylated states
Resolution4.9 Å
Binding residue
(original residue number in PDB)		C41 C44 H74 C77
Binding residue
(residue number reindexed from 1)		C25 C28 H58 C61
Annotation score4
Enzymatic activity
Enzyme Commision number 6.3.2.-
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
GO:0097602 cullin family protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007346 regulation of mitotic cell cycle
GO:0016567 protein ubiquitination
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0051301 cell division
GO:0051445 regulation of meiotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005680 anaphase-promoting complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a5y, PDBe:8a5y, PDBj:8a5y
PDBsum8a5y
PubMed
UniProtQ12157|APC11_YEAST Anaphase-promoting complex subunit 11 (Gene Name=APC11)

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