Structure of PDB 8fky Chain SI Binding Site BS03

Receptor Information

>8fky Chain SI (length=229) Species: 9606 (Homo sapiens)

KIPLVPENLLKKRKAYQALKATQAKQALLARFKRLESFLHDSWRQKRDKV
RLRRLEVKPHALELPDKHSLAFVVRIERIDGVSLLVQRTIARLRLKKIFS
GVFVKVTPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPL
TDNTVIEEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLSVARHA
TKNRVGFLKEMGTPGYRGERINQLIRQLN

Ligand information

>8fky Chain L3 (length=2585)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagagguaaacgggugggguccgcgcaguccgcccggag
gauucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggug
cgccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggc
ucgggcccgaguguuacagcccccccggcagcagcacucgccgaaucccg
gggccgagggagcgccgcgcucuccggccgggccaggccacggagcgcac
ggggucggcggcgacgucggcuacccacccgacccgucuugaaacacgga
ccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccg
uggcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgu
cucgcccggggagguggagcacgagcgcacguguuaggacccgaaagaug
gugaacuaugcaagccagaggaaacucugguggguauaggggcgaaagac
uaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgcu
cucgcgcaguuuuauccgguggguaagaagcccggcucgagccgggcgug
gaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcg
ggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagac
cccagaaaagguguugguugauauagacagcaggacgguggccauggaag
ucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
ccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccg
gcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuug
aagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggu
gguaguagcuucaaacgagaacuuugaaggccgaaguggagaaggguucc
auguacaugggucagucgguccuagggacgggcgauggccuccggcccgc
cggggagucggguucagauccccgaauccggaguggcggagaugggcgcc
gcgaggcguccagugcgguaacgcgaccgaucccggagaagccggcggga
gccccggggagaguucucuuuucuuugugaagggcagggcgcccuggaau
ggguucgccccgagagaggggcccgugccuuggaaagcgucgcgguuccg
gcggcguccggugagcucucgcuggcaauccgggggagaggguguaaauc
ucgcgccgggccguacccuccaaggugaacagccucuggcaauguaggua
agggaagucgggaauccgauucccacugucccuaccuacuauccagcgaa
accacagccaagggaacgggcuuggcggaaucagcggggagaagacccug
uugagcuugacucuagucuggcacggugaagagacaugagagguguagaa
uaagugggaggcggccgccggugaaauaccacuacucugaucguuuuuuc
cagugccagguggggaguuauccuucugaccuuuuggguuuuaagcagga
ggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgc
gacgucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaau
ucaccaagcguuggauuguucacccacuaauagggaacgugagcugggga
ccgucgugagacagguuagucccuacugaugguuguugccaugguaaucc
ugcucaguacgagaggaaccgcagguucagacauuugguggugcuuggcu
gaggagccaauggggcgaagcuaccaucugugggauuaugacugaacgcc
ucuaagucagaaucccgcccaggcggaacgauacagcgccgcggagccuc
gguuggccucggauagccgguccccgggguccggugcggagugcccuucg
uccugggaaacggggcgcggccggagaggcggccgcccccucgcccguca
cgcaccgcacguucguggggaaccuggcgcuaaaccauucguagacgacc
ugcuucugggucgggguuucguacguagcagagcagcucccucgcugcga
ucuauugaaagucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
.....................<<<<<<<<..<<<.<<...<<<<<<<<.<
<<.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>..
.<<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<
<<<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>
>>>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>..
....>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><
<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>....
.>>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<
<<<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<
<<...<<<<<...<<<<<<<....>>>>>>>...>>>>><<.<....>.>
>.>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<<
<....<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>...
.>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..
........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.......
..>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>
>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<
<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<<<<<<<.......>>>>>>.<<<.....<<<<..<<...<<
<<<..>>>>>....((<<<<<...<<...<<<<...........>>>>.>
>..>...<<<<<........>>>>>))<<<<....<<<<<...<<<<<<<
....>>>>>>>...<<<....>>>......<<<<<<<...<<<<<<<<<<
<..<<<<<<<<<<.......>>>>>>.....<<<<.<<<<.<<<<.....
<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<<.......
>>>>>>>>>>>....>>>>>>>>>>>..>>>>>>>.............>>
.>>>.>>>>>>>>..>>>>>>.<<<<.....>>>>..>>>...<<<<<<.
<<<<<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>...
.>>...<<<<<<........>>>>>>....<<<<.<<<<......<<<<<
<.<<<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<........
..<<<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>
..>>>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>
>>........>>>>>.>.>>>>>>.............<<<<<<...<..>
...>>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>
>>>>...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<
<<<<<....>>>.>>>>...>>>>.>>>>..<<<<<<.<..<<<..<.<<
<<<.................>>>>>.><<<<....<<<<.<<.<<<<<<<
....>>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<.......
....>>>>>...>>>>>.>>>...>.>>>>>>..<<<<<<<.<<..<<<<
....<<<........<<<<<.<<<<>>>>.>>>>>.......>>>...<<
<..<<<<....<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>
>>..............>>>>..>>>>>>>>><<<<<.<............
.>....<<.<<<<<<<.<<.....<<<<.<..<<<<<......>>>>>..
>>>>>....>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fky Principles of human pre-60 S biogenesis.
• Resolution: 2.67 Å
• Binding residue (original residue number in PDB): I18 L20 Y32 K36 A223 R224 H225
• Binding residue (residue number reindexed from 1): I2 L4 Y16 K20 A197 R198 H199

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0001825 blastocyst formation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fky, PDBe:8fky, PDBj:8fky
• PDBsum: 8fky
• PubMed: 37410842
• UniProt: Q6DKI1|RL7L_HUMAN Ribosomal protein uL30-like (Gene Name=RPL7L1)