Structure of PDB 8fkw Chain SI Binding Site BS03

Receptor Information

>8fkw Chain SI (length=223) Species: 9606 (Homo sapiens)

ENLLKKRKAYQALKATQAKQALLARFKRLESFLHDSWRQKRDKVRLRRLE
VKPHALELPDKHSLAFVVRIERIDGVSLLVQRTIARLRLKKIFSGVFVKV
TPQNLKMLRIVEPYVTWGFPNLKSVRELILKRGQAKVKNKTIPLTDNTVI
EEHLGKFGVICLEDLIHEIAFPGKHFQEISWFLCPFHLSVARHATKNRVG
FLKEMGTPGYRGERINQLIRQLN

Ligand information

>8fkw Chain L3 (length=2277)

gcgaccucagaucagacguggcgacccgcugaaagcauauuagucagcgg
aggagaagaaacuaaccaggauucccucaguaacggcgagugaacaggga
agagcccagcgccgaauccccgccccgggggcgcgggacauguggcguac
ggaagacccgcuccccggcgccgcucguggggggcccaaguccuucugau
cgaggcccagcccguggacggugugaggccgguagcggcccccggcgcgc
cgggcccgggucuucccggagucggguugcuugggaaugcagcccaaagc
gggugguccaucuaaggcuaaauaccggcacgagaccgauagucaacaag
uaccguaagggaaaguugaaaagaacuuugaagagagaguucaagagggc
gugaaaccguuaagaggaacgggugggguccgcgcaguccgcccggagga
uucaacccggcggcggccgccgccgggcgcauuuccaccgcggcggugcg
ccgcgaccggcuccgggacggcugggaaggcccggcggggaagguggcuc
gggcccgaguguuacagcccccccggcagcagcacucgccgaaucccggg
gccgagggagcgccgcgcucuccggccgggccaggccacggagcgcacgg
ggucggcggcgacgucggcuacccacccgacccgucuugaaacacggacc
aaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccgug
gcgcaaggugggaucccgaggcccgccgagggcgcaccaccggcccgucu
cgcccggggagguggagcacgagcgcacguguuaggacccgaaagauggu
gaaaccaucuaguagcugguucccuccgaaguuucccggauagcuggcgc
ucuccgcaguuuuauccgguggguaagaagcccggcucgagccgggcgug
gaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcg
ggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagac
cccagaaaagguguugguugauauagacagcaggacgguggccauggaag
ucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
ccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccg
gcagucacgcuacgccgcgacgaguaggagggccgcugcggugagccuug
aagccuagggcgcgggcccggguggagccgccgcaggugcagaucuuggu
gguaguagcauucaaacgagaacuuugaaggccgaaguggagaaggggcg
auggccuccggcccucgcggagaugggcgccgcgaggcguccagugaauc
ucgcccgcagcaggucuccggugaacagccucuggcaauguagguaaggg
aagucgggaauccgauucccacugucccuaccuacuauccagcgaaacca
cagccaagggaacgggcuuggcggaaucagcggggagaagacccuguuga
gcuugacucuagucuggcacggugaagagacaugagagguguagaauaag
ugggaggcggccgccggugaaauaccacuacucugaucguuuuuuccagu
gccagguggggaguuauccuucugaccuuuuggguuuuaagcaggaggug
ucagaaaaguuaccacagggauaacuggcuuguggcggccaagcgcgacg
ucgcuuuuugaugaugucggcucuuccuaucauugugaagcagaauucac
caagcguuggauuguucacccacuaauagggaacgugagcuggggaccgu
cgugagacagguucccuacugaugguuguugccaugguaauccugcucag
uacgagaggaaccgcagguucagacauuugguggugcuuggcugaggagc
caauggggcgaagcuaccaucugugggauuaugacugaacgccucuaagu
cagaaucccgcccaggcggaacgauaagcgccgcggagccucgguuggcc
ucggauagccgguccccgggguccggugcggagugcccuucguccuggga
aacggggcgcggccggagaggcggccgcccccucgcccgucacgcaccgc
acguucguggggaaccuggcgcuaaaccauucguagacgaccugcuucug
ggucgggguuucguacguagcagagcagcucccucgcugcgaucuauuga
aagucagcccucgacacaaggguuugu

........................<<<<<<...............>>>>>
.>.........<<....>>..<<<<<<.....<<.....>>....>>>>>
>..<<<..<<<<<...<<<<<<<<<<.>>>>>>.>>>>.....>>>>>..
<<<<<<<<<<...<<<<<<<<.<<.....<<<<<<<<....<<<<.....
.>>>>.....((......<<<.....))>>>...>.>>>>>>>.>>>>>>
>>>>..>>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<<.>>>>>>..>>>................................
..<<....>>...............<<<<....>>>>.............
...................<<<<<<<<.<<<<.<<...<<<<<<<<.<<<
.....<<<<<<<<<<..>>>>>>>>>>......>>>.>>>.>>>>>...<
<<<<<<.<<<<<<<<<<<<<<<...<<..<<<.<<.<<<<......<<<<
<<..>>>>>>.......>>>>>>.>>>........>>>>>>..>>>>>>>
>>>>..........<<<<<<.<..>.<<<<<<.>>>>.>>>>>>>>....
..>>.>>>>>...>>>>>..>>>>>>>>>..<<<<.<....>.>>>><<<
<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>.....>
>>....<<<<<...<<<..<<<..>>>..>>>....>>>>>.<<<<<<<<
<.<<..>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<
...>>>>>>......>.>>..<<<<<<......<<<.>>>..<<.<<<<<
<<...<<<.<<<<<<<<...>>>>>>...<<<<<<<<..>>>>>>>>...
.>>>>>>>>>>>>..>>..<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..
........<<<.<<<<<<<<<<.....<.<<<<<.<<<...<<.......
..>>...>>>.........<<......>>...>>>>>.>.>>>>>>>>>>
>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<
<<...........>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<....
..<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>>>>
<<.....<<.<<<<<<.......>>>>>>.<<<<....<<<<...<<<<.
..........>>>>..<<<<<...<<<<<<<....>>>>>>>......>>
.>>><<......>>.>>>><<<.....>>>..>>>>...<<<<<<.<<<<
<<<<..<<<<<<.>>>>>>.>>>.>>>>>>>>>>>......>>....>>.
..<<<<<<........>>>>>>....<<<<.<<<<......<<<<<<.<<
<<<<.<<<<<.<<<<<<<<<...<<<<<<<<<<.<<<<..........<<
<<<..<<<.>>>............>>>>>.>>>>.>>.>>>>>>>>..>>
>>>>>>>..>>>>>...<<<<<<<..<<<.........>>>>>>>>>>..
......>>>>>.>.>>>>>>.............<<<<<<...<..>...>
>>>>>.......((...<<<<<<<<<<<..<.<.<<<<<......>>>>>
...>.>.<<<.....))..>>>.....>>>>>....>>>>>>..<<<<<<
<....>>>.>>>>>>>>.>>>>..<<<<<<.<..<<<..<.<<<<<....
.............>>>>>.><<<<....<<<<.<<.<<<<<<<....>>>
>>..>>.>>...>>>>...>>>><<<<<...<<<<<...........>>>
>>...>>>>>.>>>...>.>>>>>>.<<<<<<<.<<..<<<<....<<<.
.......<<<<<.<<<<>>>>.>>>>>.......>>>...<<<..<<<<.
...<<<<.<<<<<<<......>>>>>>>>>>>...>>>>..>>>......
........>>>>..>>>>>>>>><<<<<.<.............>....<<
.<<<<<<<.<<.....<<<<....<<<<<......>>>>>...>>>>...
.>>....>>>>.>>>.>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fkw Principles of human pre-60 S biogenesis.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): Y32 K36 R224 H225
• Binding residue (residue number reindexed from 1): Y10 K14 R192 H193

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0001825 blastocyst formation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fkw, PDBe:8fkw, PDBj:8fkw
• PDBsum: 8fkw
• PubMed: 37410842
• UniProt: Q6DKI1|RL7L_HUMAN Ribosomal protein uL30-like (Gene Name=RPL7L1)