Structure of PDB 7yed Chain R Binding Site BS03

Receptor Information
>7yed Chain R (length=1254) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMILTQFGPFIESISGITDQSNDVFENAAKAFSMFTRSDVYKALDEIPFS
EDAMLPIPPTIYTKPSHDSYYYIDALNRVRRKTYQGPDDVYVPNCSIVEL
LEPHETLTSYGRLSEAIENRAKDGDSQARIATTYGRIAESQARQIKAPLE
KFVLALLVAEAGGSLYDPVLQKYDEIPGLSHNCPLWCFREICRHISGPLP
DRAPYLYLSAGVFWLMSPRMTSAIPPLLSDLVNLAILQQTAGLDPSLVRL
GVQICLHAAASSSYAWFILKTKSIFPQNTLHSMYESLEGGYCPNLEWLEP
RSDYKFMYMGAMPLSTKYARSAPSNDKKARELGEKYGLSSVVSELRRRTK
TYSKHDFTSVRYIRDAMACTSGIFLVRTPTETVLQEYTQSPEIKVPIPQK
DWTGPIGEIRILKDTTSSIARYLYRTWYLAAARMAAQPRTWDPLFQAIMR
SQYVTARGGSGATLRESLYAINVSLPDFKGLPVKAATKIFQAAQLANLPF
SHTSVAILADTSMGLRNQVQRRPRSIMPLNVPQQQVSAPHTLTADYINYH
MNLSTTSGSAVIEKVIPLGVYASSPPNQSINIDISACDASITWDFFLSVI
MAAIHEGVASSSIGKPFMGVPASIVNDESVVGVRAARPISGMQNMIQHLS
KLYKRGFSYRVNDSFSPGNDFTHMTTTFPSGSTATSTEHTANNSTMMETF
LTVWGPEHTDDPDVLRLMKSLTIQRNYVCQGDDGLMIIDGNTAGKVNSET
IQKMLELISKYGEEFGWKYDIAYDGTAEYLKLYFIFGCRIPNLSRHPIVG
KERANSSAEEPWPAILDQIMGIFFNGVHDGLQWQRWIRYSWALCCAFSRQ
RGYLQYPMWSFVYWGLPLVKVFGSDPWIFSWYMPTGDLGMYSWISLIRPL
MTRWMVANGYVTDKCSPVFGNADYRKCFNELKLYQGYYMAQLPRNPKKSG
RAAPREVREQFTQALSDYLMQNPELKSRVLRGRSEWEKYGAGIIHNPPSL
FDVPHKWYQGAQEAATATREELAEMDETLMRARKHSYSSFSKLLEAYLLV
KWRMCEAREPSVDLRLPLCAGIDPLNSDPFLKMVSVGPMLQSTRKYFAQT
LFMAKTVSGLDVNAIDSALLRLRTLGADKKALTAQLLMVGLQESEADALA
GKIMLQDVNTVQLARVVNLAVPDTWMSLDFDTMFKHHVKLLPKDGRHLNT
DIPPRMGWLRAILRFLGAGMAMTATGVAVDIYLEDIHGGGRSLGQRFMTW
MRQE
Ligand information
>7yed Chain T (length=36) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB7yed In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		T457 R459 G460 S462 A464 R467 A488 S514 M515 I528 P530 G560 S561 A562 V563 S682 G683 A1123 S1126 A1179
Binding residue
(residue number reindexed from 1)		T455 R457 G458 S460 A462 R465 A486 S512 M513 I526 P528 G558 S559 A560 V561 S680 G681 A1114 S1117 A1170
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0032774 RNA biosynthetic process
Cellular Component
GO:0019013 viral nucleocapsid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yed, PDBe:7yed, PDBj:7yed
PDBsum7yed
PubMed36469786
UniProtC9E870

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