Structure of PDB 6tps Chain Q Binding Site BS03

Receptor Information
>6tps Chain Q (length=461) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDETRRLNLT
TNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEAKLLFLKSFQFILK
RQIRWLITEMRFPKEFEHVAKIIWLKILKTINDQPQEELKLQLHMTSTIS
ILYLASTHLSLPVYTCDYIKWICTAKMPYFQASEILPKSWRIQLPNYYVS
ILEGSISPFNGQLYNKIALTCGMIHFKEFFNSEISCQGLLLKLVMQCALP
PEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSNHAELRVLSYFMLT
INWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGRNIVKVVYPDKPTS
SDYFQWSEEETLEFLKWMEKQFLPTQTDQKIARRKLYKIFPLDSTHQLTF
IEDLQERYAKQTPFFPPARKEAIGRLLTHIASQLLVDFAISKEQLKDCIS
RIKNACLHRMN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6tps Chain Q Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6tps Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting.
Resolution3.54 Å
Binding residue
(original residue number in PDB)		C15 C29 H33
Binding residue
(residue number reindexed from 1)		C13 C27 H31
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001188 RNA polymerase I preinitiation complex assembly
GO:0006360 transcription by RNA polymerase I
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000120 RNA polymerase I transcription regulator complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0070860 RNA polymerase I core factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6tps, PDBe:6tps, PDBj:6tps
PDBsum6tps
PubMed32139698
UniProtP40992|RRN7_YEAST RNA polymerase I-specific transcription initiation factor RRN7 (Gene Name=RRN7)

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