Structure of PDB 6lum Chain Q Binding Site BS03

Receptor Information

>6lum Chain Q (length=238) Species: 1445611 (Mycolicibacterium smegmatis MC2 51)

AVMVTLKIARFNPENPDAAGWQSFRVPCLPSDRLLNLLHYVKWYLDGTLT
FRRSCAHGVCGSDAMRINGVNRLACKVLMRDMLPKNPNKQLTITIEPIRG
LPVEKDLVVNMEPFFDAYRAVKPFLVTSGNPPTKERIQSPTDRARYDDTT
KCILCACCTTSCPVYWSEGSYFGPAAIVNAHRFIFDSRDEAAAERLDILN
EVDGVWRCRTTFNCTEACPRGIQVTQAIQEVKRALMFA

Ligand information

• Ligand ID: F3S
• InChI: InChI=1S/3Fe.4S
• InChIKey: FCXHZBQOKRZXKS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.385: S1[Fe]S[Fe]2S[Fe]1S2
  OpenEye OEToolkits 2.0.7: S1[Fe]2S[Fe]3[S]2[Fe]1S3
• Formula: Fe3 S4
• Name: FE3-S4 CLUSTER
• PDB chain: 6lum Chain Q Residue 303

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6lum Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF.
• Resolution: 2.84 Å
• Binding residue (original residue number in PDB): C184 C230 R231 T232 T233 N235 C236 T247
• Binding residue (residue number reindexed from 1): C162 C208 R209 T210 T211 N213 C214 T225
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.3.5.1: succinate dehydrogenase.

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0051538 3 iron, 4 sulfur cluster binding

Biological Process

• GO:0006099 tricarboxylic acid cycle
• GO:0009060 aerobic respiration
• GO:0022904 respiratory electron transport chain

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:6lum, PDBe:6lum, PDBj:6lum
• PDBsum: 6lum
• PubMed: 32843629
• UniProt: A0QT07