Structure of PDB 6az3 Chain Q Binding Site BS03

Receptor Information

>6az3 Chain Q (length=189) Species: 5661 (Leishmania donovani)

VSLKLQARLASSILGCGRARVWLDPNEAVEIQNANSRKSVRKLIKDGFII
RKPVKVHSRARWRKMKEAKDMGRHNGVGRREGSREARMPSKELWMRRLRI
LRRLLRKYRADKKIDRHVYRDLYVRAKGNVFRNKRNLVEHIHKIKNEKKK
ERQLAEQLAAKHLRDEQNRNKARKQELRKREKERERARR

Ligand information

>6az3 Chain 3 (length=177)

agugguaaugcgaaacacugccagguaacaaaucaauccucccacgguga
gcuuucuuuucaccauaauccaccuugggccuuuuaccgcguuguucgga
gcgggggcucaagauugaaaaaugcagcucuacguacuguugugaguucu
gcgcauuaacgcaaaaaccuggggugu

.<<......>>.....<<<.<<<<<<.......<<...<<<<...<<<<<
<.......>>>>>><...<<.<.<<<<<<<<<<<...<<.......>>..
..>>>>>>>>>>>.>.>>....><<<<..<...>..>>>>.>.>>>...>
>...............>>>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): K39 R42 K43 K46 R52 S59 R60 A61 W63 R64 K92 W95 M96 L99 R100 R103 R110 H118 Y120 R121 Y124 K128
• Binding residue (residue number reindexed from 1): K38 R41 K42 K45 R51 S58 R59 A60 W62 R63 K91 W94 M95 L98 R99 R102 R109 H117 Y119 R120 Y123 K127

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit

External links

• PDB: RCSB:6az3, PDBe:6az3, PDBj:6az3
• PDBsum: 6az3
• PubMed: 29150609
• UniProt: A0A504XXD2