Structure of PDB 5w65 Chain P Binding Site BS03

Receptor Information
>5w65 Chain P (length=481) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSTFIRGPICGTDNCPSRLWRIIDGRRTCQYGHVMEGDVEFNDDEDDLNG
LGAGVITRRLNLTTNATGSFQSSQLTNSQLLQQQQRQSHKKFKKLIGHEA
KLLFLKSFQFILKRQIRWLITEMRFPKEFEHVAKIIWLKILKTINDQPQE
ELKLQLHMTSTISILYLASTHLSLPVYTCDYIKWICTAKMPYFQASEILP
KSWRIQLPNYYVSILEGSISPFNGQLYNKIALTCGMIHFKEFFNSEISCQ
GLLLKLVMQCALPPEFYFYTKQVIEFEETDIRNLTLWERTDERHTGRVSN
HAELRVLSYFMLTINWMLSFDRDRQYPLKWILSLTESLTQRTTTSESIGR
NIVKVVYPDKPTSSDYFQWSEEETLEFLKWMEKQFLPTQTSMEMTIDQKI
ARRKLYKIFPLDREDSTHQLTFIEDLQERYAKQTPFFPPARKEAIGRLLT
HIASQLLVDFAISKEQLKDCISRIKNACLHR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5w65 Chain P Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5w65 Structural mechanism of ATP-independent transcription initiation by RNA polymerase I.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		C10 C15 C29
Binding residue
(residue number reindexed from 1)		C10 C15 C29
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001164 RNA polymerase I core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001188 RNA polymerase I preinitiation complex assembly
GO:0006360 transcription by RNA polymerase I
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000120 RNA polymerase I transcription regulator complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0070860 RNA polymerase I core factor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5w65, PDBe:5w65, PDBj:5w65
PDBsum5w65
PubMed28623663
UniProtP40992|RRN7_YEAST RNA polymerase I-specific transcription initiation factor RRN7 (Gene Name=RRN7)

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