Structure of PDB 1h71 Chain P Binding Site BS03

Receptor Information
>1h71 Chain P (length=455) Species: 76981 (Pseudomonas sp. 'TAC II 18') [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTSSAFTQIDNFSHFYDRGDHLVNGKPSFTVDQVADQLTRSGASWHDLNN
DGVINLTYTFLTAPPVGYASRGLGTFSQFSALQKEQAKLSLESWADVAKV
TFTEGPAAGDDGHQTFANFSASNGGAAFAYLPNSSRKGESWYLINKDYQV
NKTPGEGNYGRQTLTHEIGHTLGLSHPGDYNPTYRDAVYAEDTRAYSVMS
YWSEKNTGQVFTKTGEGAYASAPLLDDIAAVQKLYGANLETRADDTVYGF
NSTADRDFYSATSSTDKLIFSVWDGGGNDTLDFSGFSQNQKINLTAGSFS
DVGGMTGNVSIAQGVTIENAIGGSGNDLLIGNDAANVLKGGAGNDIIYGG
GGADVLWGGTGSDTFVFGAVSDSTPKAADIIKDFQSGFDKIDLTAITKLG
GLNFVDAFTGHAGDAIVSYHQASNAGSLQVDFSGQGVADFLVTTVGQVAT
YDIVA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain1h71 Chain P Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB1h71 Crystal Structures of a Psychrophilic Metalloprotease Reveal New Insights Into Catalysis by Cold-Adapted Proteases
Resolution2.1 Å
Binding residue
(original residue number in PDB)		G349 A350 G351 D353 G366 T368 D371
Binding residue
(residue number reindexed from 1)		G341 A342 G343 D345 G358 T360 D363
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.40: serralysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0005509 calcium ion binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1h71, PDBe:1h71, PDBj:1h71
PDBsum1h71
PubMed12577270
UniProtO69771

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