Structure of PDB 8asc Chain O Binding Site BS03

Receptor Information
>8asc Chain O (length=498) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGRDSLIFLVDASKAMFESQSEDELTPFDMSIQCIQSVYISKIISSDRDL
LAVVFYGTEKDKNSVNFKNIYVLQELDNPGAKRILELDQFKGQQGQKRFQ
DMMGHGSDYSLSEVLWVCANLFSDVQFKMSHKRIMLFTNEDNPHGNDSAK
ASRARTKAGDLRDTGIFLDLMHLKKPGGFDISLFYRDIISILRVHFEESS
KLEDLLRKVRAKETRKRALSRLKLKLNKDIVISVGIYNLVQKALKPPPIK
LYRETNEPVKTKTRTFNTSTGGLLLPSDTKRSQIYGSRQIILEKEETEEL
KRFDDPGLMLMGFKPLVLLKKHHYLRPSLFVYPEESLVIGSSTLFSALLI
KCLEKEVAALCRYTPRRNIPPYFVALVPQEEELDDQKIQVTPPGFQLVFL
PFADDKRKMPFTEKIMATPEQVGKMKAIVEKLRFTYRSDSFENPVLQQHF
RNLEALALDLMEPEQAVDLTLPKVEAMNKRLGSLVDEFKELVYPPDYN
Ligand information
>8asc Chain T (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RRRCPGESLINPGFKSKKPAGGVDFDET
Receptor-Ligand Complex Structure
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PDB8asc PAXX binding to the NHEJ machinery explains functional redundancy with XLF.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		K74 H163 R244 E250 R252 I425 E467 R470 F471 R474 D476 L506 R517
Binding residue
(residue number reindexed from 1)		K42 H131 R207 E213 R215 I388 E430 R433 F434 R437 D439 L469 R480
Enzymatic activity
Enzyme Commision number 3.6.4.-
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0042162 telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining
Cellular Component
GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asc, PDBe:8asc, PDBj:8asc
PDBsum8asc
PubMed37256950
UniProtP12956|XRCC6_HUMAN X-ray repair cross-complementing protein 6 (Gene Name=XRCC6)

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