Structure of PDB 6rie Chain O Binding Site BS03

Receptor Information
>6rie Chain O (length=822) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDANVVSFSTIATYIDALAKNASELEQRSTAYEINNELELVFIKPPLITL
TNVVNISTIQESFIRFTVTNKEGVKIRTKIPLSKVHGLDVKNVQLVDAID
NIVWEKKSLVTENRLHKECLLRLSTEERHIFLDYKKYGSSIRLELVNLIQ
AKTKNFTIDFKLKYFLGSGAQSKSSLLHAINHPKSRPNTSLEIEFTPRDN
ETVPYDELIKELTTLSRHIFMASPENVILSPPINAPIKTFMLPKQDIVGL
DLENLYAVTKTDGIPITIRVTSNGLYCYFTHLGYIIRYPVKRIIDSEVVV
FGEAVKDKNWTVYLIKLIENDRLEESKYVESKLVDICDRIVFKSKKYEGP
FTTTSEVVDMLSTYLPKQPEGVILFYSKGPKSNIDFKIKKENTIDQTANV
VFRYMSSEPIIFGESSIFVEYKKFSNDKGFPKEYGSGKIVLYNGVNYLNN
IYCLEYINTHNEVGIKSVVVPIKFIAEFLVNGEILKPRIDKTMKYINSED
YYGNQHNIIVEHLRDQSIKIGDINDKFRLNPEVSYFTNKRTRGPLGILSN
YVKTLLISMYCSKTFLDDSNKRKVLAIDFGNGADLEKYFYGEIALLVATD
PDADAIARGNERYNKLNSKTKYYKFDYIQETIRSDTFVSSVREVFYFGKF
NIIDWQFAIHYSFHPRHYATVMNNLSELTASGGKVLITTMDGDKLSKLTD
KKTFIIHKNLPSSENYMSVEKIADDRIVVYNPSTMSTPMTEYIIKKNDIV
RVFNEYGFVLVDNVDFATIIERSKKFINGASTMEDRPSTKNFFELNRGAI
KCEGLDVEDLLSYYVVYVFSKR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6rie Chain O Residue 902 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rie Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E39 E194
Binding residue
(residue number reindexed from 1)		E39 E194
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.7.7.50: mRNA guanylyltransferase.
3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004484 mRNA guanylyltransferase activity
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008168 methyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0050355 inorganic triphosphate phosphatase activity
GO:0140818 mRNA 5'-triphosphate monophosphatase activity
Biological Process
GO:0006353 DNA-templated transcription termination
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6rie, PDBe:6rie, PDBj:6rie
PDBsum6rie
PubMed31835031
UniProtP04298|MCEL_VACCW mRNA-capping enzyme catalytic subunit (Gene Name=OPG113)

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