Structure of PDB 8fl0 Chain NC Binding Site BS03

Receptor Information
>8fl0 Chain NC (length=432) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRDRATIRRLNMYRQKERRNSRGKIIKPLQYQSTVASGTVARVEPNIKWF
GNTRVIKQSSLQKFQEEMKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHIL
DTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVTE
DTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSP
HIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASL
TNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKV
CNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVE
KIKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKG
GEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8fl0 Chain NC Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fl0 Principles of human pre-60 S biogenesis.
Resolution2.91 Å
Binding residue
(original residue number in PDB)		S324 T345
Binding residue
(residue number reindexed from 1)		S289 T310
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0008150 biological_process
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8fl0, PDBe:8fl0, PDBj:8fl0
PDBsum8fl0
PubMed37410842
UniProtQ13823|NOG2_HUMAN Nucleolar GTP-binding protein 2 (Gene Name=GNL2)

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