Structure of PDB 5mq0 Chain N Binding Site BS03

Receptor Information

>5mq0 Chain N (length=227) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EINEPPPNICEQCLGDEANIRMTKIPQGSECKICTLPFTLYHFKTSKRSN
NIIKTLICVRCATQRNICQCCMLDSRWHIPIQLRDHLISLVNEENVMTEE
AKNDMMKRFLSLKNVKLGGAQITSDPSEADNIVDKLKNILLKNPSTKSFF
LYNIDASIPEWKITDTVSQLLLSLIVNHKAKCGGLRFQSSELGERFVSKI
IFIIPWSSTAENIKLSLSLNKLIQLEL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5mq0 Chain N Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5mq0 Structure of a spliceosome remodelled for exon ligation.
Resolution	4.17 Å
Binding residue (original residue number in PDB)	C13 C16 C71 C74
Binding residue (residue number reindexed from 1)	C10 C13 C68 C71
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0017070	U6 snRNA binding
GO:0036002	pre-mRNA binding

	Biological Process
GO:0000398	mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing

	Cellular Component
GO:0000974	Prp19 complex
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0071006	U2-type catalytic step 1 spliceosome
GO:0071007	U2-type catalytic step 2 spliceosome

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Molecular Function

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Cellular Component

External links

PDB	RCSB:5mq0, PDBe:5mq0, PDBj:5mq0
PDBsum	5mq0
PubMed	28076345
UniProt	P38241\|SLT11_YEAST Pre-mRNA-splicing factor SLT11 (Gene Name=ECM2)

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