Structure of PDB 8uk9 Chain M Binding Site BS03

Receptor Information
>8uk9 Chain M (length=317) Species: 10665 (Tequatrovirus T4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MITVNEKEHILEQKYRPSTIDECILPAFDKETFKSITSKGKIPHIILHSP
SPGTGKTTVAKALCHDVNADMMFVNGSDCKIDFVRGPLTNFASAASFDGR
QKVIVIDEFCRSGLAESQRHLRSFMEAYSSNCSIIITANNIDGIIKPLQS
RCRVITFGQPTDEDKIEMMKQMIRRLTEICKHEGIAIADMKVVAALVKKN
FPDFRKTIGELDSYSSKGVLDAGILSLVTNDAIDDVLESLKNKDVKQLRA
LAPKYAADYSWFVGKLAEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTE
LHLAYLFIQLACEMQWK
Ligand information
Ligand IDAF3
InChIInChI=1S/Al.3FH/h;3*1H/q+3;;;/p-3
InChIKeyKLZUFWVZNOTSEM-UHFFFAOYSA-K
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al](F)F
FormulaAl F3
NameALUMINUM FLUORIDE
ChEMBL
DrugBank
ZINC
PDB chain8uk9 Chain M Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8uk9 Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
Resolution3.1 Å
Binding residue
(original residue number in PDB)		P52 K56 E108 N139 R205
Binding residue
(residue number reindexed from 1)		P52 K56 E108 N139 R205
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006281 DNA repair
GO:0039686 bidirectional double-stranded viral DNA replication
GO:0039693 viral DNA genome replication
Cellular Component
GO:0005663 DNA replication factor C complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uk9, PDBe:8uk9, PDBj:8uk9
PDBsum8uk9
PubMed38177685
UniProtP04526|LOADL_BPT4 Sliding-clamp-loader large subunit (Gene Name=44)

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