Structure of PDB 8s52 Chain M Binding Site BS03

Receptor Information
>8s52 Chain M (length=289) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSERVGDSQNPLLSD
GDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADR
INLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTF
KEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQ
VQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDI
AGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL
Ligand information
>8s52 Chain T (length=64) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ctggccctcgctgtcaaaattgcggctgggtgtgcgcccccacccccttt
tatagccccccttc
Receptor-Ligand Complex Structure
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PDB8s52 Three-step mechanism of promoter escape by RNA polymerase II
Resolution2.9 Å
Binding residue
(original residue number in PDB)		D69 S70 N103 R105 M115 R154 K178 G247 R248 S249 S252 V283 T284
Binding residue
(residue number reindexed from 1)		D42 S43 N76 R78 M88 R127 K151 G220 R221 S222 S225 V256 T257
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000993 RNA polymerase II complex binding
GO:0003677 DNA binding
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016251 RNA polymerase II general transcription initiation factor activity
GO:0016407 acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
GO:0046966 nuclear thyroid hormone receptor binding
GO:0061733 peptide-lysine-N-acetyltransferase activity
GO:0140297 DNA-binding transcription factor binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0001174 transcriptional start site selection at RNA polymerase II promoter
GO:0006338 chromatin remodeling
GO:0006352 DNA-templated transcription initiation
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0010467 gene expression
GO:0019083 viral transcription
GO:0051123 RNA polymerase II preinitiation complex assembly
GO:0051177 meiotic sister chromatid cohesion
GO:0051225 spindle assembly
GO:0051276 chromosome organization
GO:0070897 transcription preinitiation complex assembly
GO:1904798 positive regulation of core promoter binding
GO:1990114 RNA polymerase II core complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0000793 condensed chromosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005669 transcription factor TFIID complex
GO:0005694 chromosome
GO:0016604 nuclear body
GO:0032153 cell division site
GO:0032993 protein-DNA complex
GO:0042585 germinal vesicle
GO:0090575 RNA polymerase II transcription regulator complex
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8s52, PDBe:8s52, PDBj:8s52
PDBsum8s52
PubMed38604172
UniProtQ00403|TF2B_HUMAN Transcription initiation factor IIB (Gene Name=GTF2B)

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