Structure of PDB 6ugm Chain M Binding Site BS03

Receptor Information
>6ugm Chain M (length=188) Species: 284590 (Kluyveromyces lactis NRRL Y-1140) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YQQIEQNGIIRDNQIALNEKEFDSTLASTTGSFIAEGFKKIPDKLKSSNQ
LTKRKKPVTFARSAIHNWGLYALEPIAAKEMIIEYVGESIRQPVAEMREK
RYIKSGIGSSYLFRIDENTVIDATKRGGIARFINHCCEPSCTAKIIKVDG
RKRIVIYALRDIGTNEELTYDYKFPCLCGAPSCKGFLN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6ugm Chain M Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ugm Structural Basis of H2B Ubiquitination-Dependent H3K4 Methylation by COMPASS.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		C990 A992
Binding residue
(residue number reindexed from 1)		C178 A180
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.354: [histone H3]-lysine(4) N-trimethyltransferase.
Gene Ontology
Molecular Function
GO:0042800 histone H3K4 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6ugm, PDBe:6ugm, PDBj:6ugm
PDBsum6ugm
PubMed31733991
UniProtQ6CIT4|SET1_KLULA Histone-lysine N-methyltransferase, H3 lysine-4 specific (Gene Name=SET1)

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