Structure of PDB 1bqq Chain M Binding Site BS03
Receptor Information
>1bqq Chain M (length=174) Species:
9606
(Homo sapiens) [
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IQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVP
YAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDT
HFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQW
MDTENFVLPDDDRRGIQQLYGGES
Ligand information
Ligand ID
ZN
InChI
InChI=1S/Zn/q+2
InChIKey
PTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Zn+2]
Formula
Zn
Name
ZINC ION
ChEMBL
CHEMBL1236970
DrugBank
DB14532
ZINC
PDB chain
1bqq Chain M Residue 290 [
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Receptor-Ligand Complex Structure
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PDB
1bqq
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor.
Resolution
2.75 Å
Binding residue
(original residue number in PDB)
H186 D188 H201 H214
Binding residue
(residue number reindexed from 1)
H73 D75 H88 H101
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
H239 H243 H249
Catalytic site (residue number reindexed from 1)
H126 H130 H136
Enzyme Commision number
3.4.24.80
: membrane-type matrix metalloproteinase-1.
Gene Ontology
Molecular Function
GO:0004222
metalloendopeptidase activity
GO:0008237
metallopeptidase activity
GO:0008270
zinc ion binding
Biological Process
GO:0006508
proteolysis
Cellular Component
GO:0031012
extracellular matrix
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:1bqq
,
PDBe:1bqq
,
PDBj:1bqq
PDBsum
1bqq
PubMed
9724659
UniProt
P50281
|MMP14_HUMAN Matrix metalloproteinase-14 (Gene Name=MMP14)
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