Structure of PDB 8rxh Chain Lj Binding Site BS03

Receptor Information

>8rxh Chain Lj (length=81) Species: 347515 (Leishmania major strain Friedlin)

TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFKTPK

Ligand information

>8rxh Chain L7 (length=166)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagu
aaagugcgauaagugguaucaauugcagaaucauucaauuaccgaaucuu
ugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugcca
uauucucagugucgaa

.........................................<<<<<<<<<
....>>>>.....(<<<<......>>.............>>>>.)...>>
>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>......
................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
• Resolution: 2.93 Å
• Binding residue (original residue number in PDB): R20 R21 C22 R44 T59 G60 T61 G62 R63 C64 R65 Y66 L67 R72 R73 I74 N76 H77 K79 T80 P81
• Binding residue (residue number reindexed from 1): R19 R20 C21 R43 T58 G59 T60 G61 R62 C63 R64 Y65 L66 R71 R72 I73 N75 H76 K78 T79 P80

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
• PDBsum: 8rxh
• PubMed: 38722744
• UniProt: E9AEH2