Structure of PDB 8rxx Chain LQ Binding Site BS03

Receptor Information
>8rxx Chain LQ (length=201) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSLKLQARLASSILGCGRARVWLDPNEAVEIQNANSRKSVRKLIKDGFII
RKPVKVHSRARWRKMKEAKDMGRHNGVGRREGSREARMPSKELWMRRLRI
LRRLLRKYRADKKIDRHVYRDLYMRAKGNVFRNKRNLVEHIHKIKNEKKK
ERQLAEQLAAKHLRDEQNRNKARKQELKKREKERERARRDDAAAAAQKKK
A
Ligand information
>8rxx Chain L3 (length=183) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agugguaaugcgaaacacuugccagguaacaaaucaauccucccacggug
agcuuucuuuucaccauaauccaccuugggccuuuuuacuuucgcguugu
ucggagcgggggcucaagauugaaaaaugcagcucuuacugucauuugug
aguucugcgcauuaaagcaaaaaccuggggugu
.<<......>>.....<<<..<<<<<<.......<<...<<<....<<<<
<<.......>>>>>><...<<.<.<<<<<<<<<<<.......<<......
.>>....>>>>>>>>>>>.>.>>....><..<..........>..>...>
>>...>>...............>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB8rxx Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
Resolution2.97 Å
Binding residue
(original residue number in PDB)		R42 K43 K46 R52 S59 R60 W63 R64 W95 M96 L99 R100 R103 R110 R117 H118 Y120 R121 Y124 K128
Binding residue
(residue number reindexed from 1)		R41 K42 K45 R51 S58 R59 W62 R63 W94 M95 L98 R99 R102 R109 R116 H117 Y119 R120 Y123 K127
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rxx, PDBe:8rxx, PDBj:8rxx
PDBsum8rxx
PubMed38722744
UniProtQ4QJ37

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