Structure of PDB 8rxh Chain LG Binding Site BS03

Receptor Information

>8rxh Chain LG (length=241) Species: 347515 (Leishmania major strain Friedlin)

VASHFAARPKNFGIGQDVPYARDLSRFMRWPTFVTMQRKKRVLQRRLKVP
PALNQFTKVLDRASRNEALKLIKKYAPETRKARRERLQKVAEEKKKDPKK
TVSTKAPLAVVTGLQEVTRAIEKKQARMVVIANNVDPVELVLWMPNLCRA
NKIPYAIVKDMARLGDAIGRKTATCVALTDVNAEDEATLKNLIRSVNARF
LSRSDVIRRQWGGLQLSLRSRAELRKKHARNAGVDAAAIIQ

Ligand information

>8rxh Chain L7 (length=166)

aacgugucgcgauggaugacuuggcuuccuauuucguugaagaacgcagu
aaagugcgauaagugguaucaauugcagaaucauucaauuaccgaaucuu
ugaacgcaaacggcgcaugggagaagcucgugucauccccgugcaugcca
uauucucagugucgaa

.........................................<<<<<<<<<
....>>>>.....(<<<<......>>.............>>>>.)...>>
>....<<.....>><<<<<<<.<..<<....>>..>.>>>>>>>......
................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8rxh Structural and mechanistic insights into the function of Leishmania ribosome lacking a single pseudouridine modification.
• Resolution: 2.93 Å
• Binding residue (original residue number in PDB): F56 V57 Q60 R61 R64 R88 K182 D183 R186
• Binding residue (residue number reindexed from 1): F33 V34 Q37 R38 R41 R65 K159 D160 R163

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0000470 maturation of LSU-rRNA

Cellular Component

• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8rxh, PDBe:8rxh, PDBj:8rxh
• PDBsum: 8rxh
• PubMed: 38722744
• UniProt: Q4QIP1