Structure of PDB 7ojl Chain L Binding Site BS03

Receptor Information
>7ojl Chain L (length=1498) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVESLNVLLDNRSSHYEEIIASCHQGINNKLTAHEVKLQIEEEYQVFRNR
LRKGEITGQFLKVDKSRLLNDFNNLYVDEVTATKDNIEHLIYQFKRASPI
LRFLYANIGKECQMQYWRSFLNKVKSLRILNTRRKLLLIFDALILLASIH
DQTRHKCSKGWLGSCFISVNDRLVSLESTKRDLEKWVGRRQQSERPPDKN
QILISMFQKTILKATAALKDVGISVEHYKINMEVICPDSYDLILNFDVSG
VVPTISYQRTEDEKFPFIMGGVELLESTDLERLSSLSLALVNSMKTSSTV
KLRQNEFGPARYQVVRCKEAYCQEFLLSGAEFQLIYQKTGECSKCYAIND
NRVGEICSFYADPKRYFPAIFSAEVLQTTVSTMISWVKDCSELEEQLCNI
NSLTKMILVLILAHPSKRSQKLLQNLRYFIMAYVSDYHHKDLIDKLREEL
ITDVEFLLYRLVRALVNLILSEDVKSMMTNRFKFILNISYMCHFITKETP
DRLTDQIKCFEKFLEPKLEFGHVSINPADVATEEELDDMVYNAKKFLSKE
GCTSIKGPDYKKPGVSKRFLSLLTSSFNNGSLFKESEVKREIKDPLVLDL
ASNKSVVVNKYTDGSRVLNYDFNKLTALAVSQLTEVFSRKGKHLLNKQDY
DYKVQQAMSNLVLLLDGGASVYFDQLKETVERIIDQYRQPSVNDLDEVVP
NKFYIRLIKGELSNHMVEDFDYDVLPGNFYEEFCDAVYKNNKLKERYFYC
GTKAVATRTYFDQEYFQCFKSILLIMNANLNFKFDMGRLSDDVRISERES
NSEALSKALSLTNLKNLCFYSQESPQSYSSTGPDTGRLKFSLSYKEQVGG
NRELYIGDLRTKMFTRLIEDYFEALSLQLSGSCLNNEREFENAILSMKLN
VSLAHVSYSMDHSKWGPMMCPFLFLATLQNLIFLSKDLQADIKGRDYLST
LLTWHMHKMVEIPFNVVSAMMKSFIKAQLGLKKKTTQSITEDFFYSNFQI
GVVPSHVSSILDMGQGILHNTSDFYALISERFINYAISCICGGTIDAYTS
SDDQISLFDQVLTELMQRDPEEFKTLIEFHYYMSDQLNKFVSPKSVIGRF
VAEFKSRFYVWGDEVPLLTKFVAAALHNIKCKEPHQLAETIDTIIDQSVA
NGVPVHLCNLIQKRTLSLLQYARYPIDPFLLNCETDVRDWVDGNRSYRIM
RQIERLIPDACGRIRSMLRKLYNKLKTGQLHEEFTTNYLSSEHLSSLSNL
CELLGVEPPSESDLEFSWLNLAAHHPLRMVLRQKIIYEKVPTIVKTIQNK
LSFQSSIASGFVGLCRTLGSKCVRGPNKESLYIKSIQSLISDIQGIEPLI
DSHGVQYWRVPLNIRDGNEGVISYFRPLLWDYMCISLSTAIELGAWVLGE
PKKVRVLEFFKHNPCDYFPLKPAAVGLNHIIHSLRRLYPSVFEKHILPFM
RIKFLDLCVALDVNCEALSLVSHIVKWKREEHYIVLSSELRLSHTRTH
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain7ojl Chain L Residue 2301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ojl Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D1332 E1382
Binding residue
(residue number reindexed from 1)		D1053 E1103
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.1.-.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0019079 viral genome replication
GO:0039689 negative stranded viral RNA replication
GO:0039694 viral RNA genome replication
GO:0039696 RNA-templated viral transcription
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

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Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ojl, PDBe:7ojl, PDBj:7ojl
PDBsum7ojl
PubMed34857749
UniProtA0A3S8NV63

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