Structure of PDB 8imx Chain K Binding Site BS03

Receptor Information
>8imx Chain K (length=330) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GHTNNWAVLVCTSRFWFNYRHVANTLSVYRSVKRLGIPDSHIVLMLADDM
ACNPRNPKPATVFSHKNMELNVYGDDVEVDYRSYEVTVENFLRVLTGRIP
PSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITNIELADAFEQM
WQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDPA
IGVHLMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRTDL
FQRDPKNVLITDFFGSVRKVEITTETIKLQKLMEPLKYAEQLPVAQIIHQ
KPKLKDWHPPGGFILGLWALIIMVFFKTYG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8imx Chain K Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8imx Structures of substrates- and products-bound glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis
Resolution2.85 Å
Binding residue
(original residue number in PDB)		D79 I82 E118 D120
Binding residue
(residue number reindexed from 1)		D39 I42 E78 D80
Annotation score4
Enzymatic activity
Enzyme Commision number 3.-.-.-
Gene Ontology
Molecular Function
GO:0003923 GPI-anchor transamidase activity
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0008218 bioluminescence
GO:0016255 attachment of GPI anchor to protein
Cellular Component
GO:0042765 GPI-anchor transamidase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8imx, PDBe:8imx, PDBj:8imx
PDBsum8imx
PubMed37684232
UniProtQ92643|GPI8_HUMAN GPI-anchor transamidase (Gene Name=PIGK)

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