Structure of PDB 8i0p Chain K Binding Site BS03

Receptor Information
>8i0p Chain K (length=312) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLL
ASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIH
MNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELE
KKKKQDLDDEEKTAKFIEEQVRRGLEGSALDEIMEIEEEKKRTARTDYWL
QPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTH
LETVIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRV
EGIQYEDISKLA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8i0p Chain K Residue 500 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8i0p Molecular Basis for the activation of Human spliceosome
Resolution3.4 Å
Binding residue
(original residue number in PDB)		C28 C31 H44 H50
Binding residue
(residue number reindexed from 1)		C22 C25 H38 H44
Annotation score4
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006397 mRNA processing
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0032991 protein-containing complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i0p, PDBe:8i0p, PDBj:8i0p
PDBsum8i0p
PubMed39068178
UniProtO60870|KIN17_HUMAN DNA/RNA-binding protein KIN17 (Gene Name=KIN)

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