Structure of PDB 7pmz Chain K Binding Site BS03

Receptor Information

>7pmz Chain K (length=428) Species: 100226 (Streptomyces coelicolor A3(2))

GVPEKFATLGLTYDDVLLLPGASAVLPNAVDTSSRISRNVRVNIPLLSAA
MDKVTESRMAISMARQGGVGVLHRNLSIEDQANQVDLVKRSESGMVANPI
TIHPDATLGEADALCAKFRISGVPVTDGAGKLLGIVTNRDMAFETDRSRQ
VREVMTPMPLVTGQVGISGVDAMELLRRHKIEKLPLVDGDGILKGLITVK
DFVKAEQYPHAAKDAKGRLLVGAAVGASPEALDRAQALAEAGVDFLVVDT
SHGHNSNALSWMSKIKSSVGIDVVGGNVATRDGAQALIDAGVDGIKVGVG
PGSICTTRVVAGIGVPQVTAIYEASLAARAAGVPLIGDGGLQYSGDIGKA
LAAGADTVMLGSLLAGCEESPGELQFINGKQFKVPYRGPLANVLHQLVGG
LRQTMGYVGAATIEEMESKGRFVRITSA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 7pmz Chain K Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7pmz Diversity of mechanisms to control bacterial GTP homeostasis by the mutually exclusive binding of adenine and guanine nucleotides to IMP dehydrogenase.
• Resolution: 2.03 Å
• Binding residue (original residue number in PDB): S127 E188
• Binding residue (residue number reindexed from 1): S121 E182
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.1.1.205: IMP dehydrogenase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003824 catalytic activity
• GO:0003938 IMP dehydrogenase activity
• GO:0005524 ATP binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006164 purine nucleotide biosynthetic process
• GO:0006177 GMP biosynthetic process
• GO:0006183 GTP biosynthetic process

External links

• PDB: RCSB:7pmz, PDBe:7pmz, PDBj:7pmz
• PDBsum: 7pmz
• PubMed: 35481629
• UniProt: Q9L0I7