Structure of PDB 7dde Chain K Binding Site BS03

Receptor Information
>7dde Chain K (length=525) Species: 83333,284812 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQLHGKMTATAKSCALDFLDFVNASPTPYHAVQNLAEHYMSHGFQYLSEK
SDWQSKIEPGNSYFVTRNKSSIIAFSIGKKWKPGNGFSIIATHTDSPTLR
LKPKSQKSAYGYLQVGVEKYGGGIWHTWFDRDLSLAGRVMVEEEDGRVIQ
YNVHIDRPLLRIPTLAIHLDPSANSSFSFNMETEFVPLIGLENELAKEET
SDNGDKYHHPVLLSLLANEISKSLETTIDPSKIVDFELILGDAEKARLGG
IHEEFVFSPRLDNLGMTFCASQALTKSLENNSLDNESCVRVVPSFDHEEI
GSVSAQGAESTFLPAVLQRICELGKESSLFSISMVKSFLVSADMAHAMHP
NYSSRYENSNTPFLNKGTVIKVNANQRYTTNSAGIVLLKKVAQLADVPIQ
SFVVRNDSPCGSTIGPKLAAMTGMRTLDLGNPMLSMHSCREMCGSKDFEY
AVVLFSSFFQNFANLEEKIIIDEGFSVACNTCLKIIRNDSFHCTKCFDFD
VCRDCYAKQAFLHPCPKPHFVLVRS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7dde Chain K Residue 1503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7dde Molecular and structural mechanisms of ZZ domain-mediated cargo selection by Nbr1.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		K1078 C1079 H1096 C1098
Binding residue
(residue number reindexed from 1)		K495 C496 H513 C515
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.21: aspartyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
GO:1901982 maltose binding
Biological Process
GO:0006457 protein folding
GO:0006508 proteolysis
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0000324 fungal-type vacuole
GO:0000328 fungal-type vacuole lumen
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7dde, PDBe:7dde, PDBj:7dde
PDBsum7dde
PubMed34169534
UniProtO36014;
P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q9P792

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