Structure of PDB 6rny Chain K Binding Site BS03

Receptor Information
>6rny Chain K (length=338) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVSRPEGVKIIPPQSDRQKIVLQAHNLAHTGREATLLKIANLYWWPNMRK
DVVKQLGRCQQCLITNASNKASGPILRPDRPQKPFDKFFIDYIGPLPPSQ
GYLYVLVVVDGMTGFTWLYPTKAPSTSATVKSLNVLTSIAIPKVIHSDQG
AAFTSSTFAEWAKERGIHLEFSTPYHPQSSGKVERKNSDIKRLLTKLLVG
RPTKWYDLLPVVQLALNNTYSPVLKYTPHQLLFGIDSNTPFANQDTLDLT
REEELSLLQEIRTSLYHPSTPPASSRSWSPVVGQLVQERVARPASLRPRW
HKPSTVLKVLNPRTVVILDHLGNNRTVSIDNLKPTSHQ
Ligand information
>6rny Chain J (length=53) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcgaaattccatgacagtagttagttggttttcaccacagggagaacctg
gac
Receptor-Ligand Complex Structure
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PDB6rny Retroviral integration into nucleosomes through DNA looping and sliding along the histone octamer.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		P214 E221 R222 S225 K228 K262
Binding residue
(residue number reindexed from 1)		P177 E184 R185 S188 K191 K225
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6rny, PDBe:6rny, PDBj:6rny
PDBsum6rny
PubMed31519882
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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