Structure of PDB 6lum Chain K Binding Site BS03

Receptor Information
>6lum Chain K (length=247) Species: 1445611 (Mycolicibacterium smegmatis MC2 51) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PELPPVPEGAVMVTLKIARFNPENPDAAGWQSFRVPCLPSDRLLNLLHYV
KWYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDMLPKNPNKQL
TITIEPIRGLPVEKDLVVNMEPFFDAYRAVKPFLVTSGNPPTKERIQSPT
DRARYDDTTKCILCACCTTSCPVYWSEGSYFGPAAIVNAHRFIFDSRDEA
AAERLDILNEVDGVWRCRTTFNCTEACPRGIQVTQAIQEVKRALMFA
Ligand information
Ligand IDF3S
InChIInChI=1S/3Fe.4S
InChIKeyFCXHZBQOKRZXKS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385S1[Fe]S[Fe]2S[Fe]1S2
OpenEye OEToolkits 2.0.7S1[Fe]2S[Fe]3[S]2[Fe]1S3
FormulaFe3 S4
NameFE3-S4 CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain6lum Chain K Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6lum Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF.
Resolution2.84 Å
Binding residue
(original residue number in PDB)		C184 C230 R231 T232 T233 C236 T247
Binding residue
(residue number reindexed from 1)		C171 C217 R218 T219 T220 C223 T234
Annotation score1
Enzymatic activity
Enzyme Commision number 1.3.5.1: succinate dehydrogenase.
Gene Ontology
Molecular Function
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051538 3 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0009060 aerobic respiration
GO:0022904 respiratory electron transport chain
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6lum, PDBe:6lum, PDBj:6lum
PDBsum6lum
PubMed32843629
UniProtA0QT07

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