Structure of PDB 6k1p Chain K Binding Site BS03

Receptor Information
>6k1p Chain K (length=463) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QFRESPAYVNGQLRPYQIQGVNWLVSLHKNKIAGILADEMGLGKTLQTIS
FLGYLRYIEKIPGPFLVIAPKSTLNNWLREINRWTPDVNAFILQGDKEER
AELIQKKLLGCDFDVVIASYEIIIREKSPLKKINWEYIIIDEAHRIKNEE
SMLSQVLREFTSRNRLLITGTPLQNNLHELWALLNFLLPDIFSDAQDFDD
WFSSESTEEDQDKIVKQLHTVLQPFLLRRIKSDVETSLLPKKELNLYVGM
SSMQKKWYKKILEKDESKTRLLNIMMQLRKCCNHPYLFDGAEPGPPYTTD
EHLVYNAAKLQVLDKLLKKLKEEGSRVLIFSQMSRLLDILEDYCYFRNYE
YCRIDGSTAHEDRIQAIDDYNAPDSKKFVFLLTTRAGGLGINLTSADVVV
LYDSDWNPQADLQAMDRAHRIGQKKQVKVFRLVTDNSVEEKILERATQKL
RLDQLVIQQNRTS
Ligand information
Ligand IDBEF
InChIInChI=1S/Be.3FH/h;3*1H/q+2;;;/p-3
InChIKeyOGIAHMCCNXDTIE-UHFFFAOYSA-K
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[Be-](F)(F)F
ACDLabs 10.04
CACTVS 3.341		F[Be-](F)F
FormulaBe F3
NameBERYLLIUM TRIFLUORIDE ION
ChEMBL
DrugBank
ZINC
PDB chain6k1p Chain K Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6k1p Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling.
Resolution3.87 Å
Binding residue
(original residue number in PDB)		E325 G584 R611
Binding residue
(residue number reindexed from 1)		E142 G390 R417
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.-
Gene Ontology
Molecular Function
GO:0000182 rDNA binding
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0031491 nucleosome binding
GO:0140658 ATP-dependent chromatin remodeler activity
Biological Process
GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006354 DNA-templated transcription elongation
GO:0006355 regulation of DNA-templated transcription
GO:0006363 termination of RNA polymerase I transcription
GO:0006369 termination of RNA polymerase II transcription
GO:0007062 sister chromatid cohesion
GO:0009408 response to heat
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046832 negative regulation of RNA export from nucleus
GO:1902275 regulation of chromatin organization
GO:1903895 negative regulation of IRE1-mediated unfolded protein response
Cellular Component
GO:0005634 nucleus
GO:0016587 Isw1 complex
GO:0030874 nucleolar chromatin
GO:0036436 Isw1a complex
GO:0036437 Isw1b complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6k1p, PDBe:6k1p, PDBj:6k1p
PDBsum6k1p
PubMed30872815
UniProtP38144|ISW1_YEAST ISWI chromatin-remodeling complex ATPase ISW1 (Gene Name=ISW1)

[Back to BioLiP]