Structure of PDB 6ztr Chain J Binding Site BS03

Receptor Information
>6ztr Chain J (length=213) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVF
AVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQ
NDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIH
SQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGS
TTTAVAVVEILDA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ztr Chain J Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ztr PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		N209 H211 D241 D243 N250 D302
Binding residue
(residue number reindexed from 1)		N101 H103 D133 D135 N142 D194
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ztr, PDBe:6ztr, PDBj:6ztr
PDBsum6ztr
PubMed33879555
UniProtP22223|CADH3_HUMAN Cadherin-3 (Gene Name=CDH3)

[Back to BioLiP]