Structure of PDB 2irf Chain J Binding Site BS03

Receptor Information
>2irf Chain J (length=109) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPL
FRNWAIHTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNN
AFRVYRMLP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2irf Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		R643 K701
Binding residue
(residue number reindexed from 1)		R39 K97
Binding affinityPDBbind-CN: Kd=0.17uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2irf, PDBe:2irf, PDBj:2irf
PDBsum2irf
PubMed10487755
UniProtP23906|IRF2_MOUSE Interferon regulatory factor 2 (Gene Name=Irf2)

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