Structure of PDB 7pua Chain IA Binding Site BS03

Receptor Information
>7pua Chain IA (length=704) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSQSSRGQPGLQWQEGVVDPRYSSSGNMRRFNPDTVAHYVKATIQNDRRE
MGLGEVYDWHEFAKDAVYIPTRSGPLWVGSDDPRCAKFMRRRSKMQKTPQ
QKARPKPGPDPAKALEDHPLREYFTTATNLRDPLSTANNLHRAGLIREYD
IKYTAAKVRYVPRPPVVSIMGHVDHGKTTLLDYLRKTNVASQEAGGITQN
VGAFQVKTLGDTLVTFIDTPGHAAFTTMREVGATANDLIVLVVSAVDGVQ
PQTKEVIELAHKSGIPFVVACTKIDRQPRVENVKQQLRDCNVELEEDGGD
TQFVPVCARDGRGVPELLEAIALQAELCEISTPKPSRCEVTVIETNGVNT
TTEVAGIVRCGKVRAGQVLVAGMTYAVVRKVLDEHGQIIQEAGPSQPVVL
HGFRVHPKPGSILLQVSSESHAQKFYHFMKEVYQAEGRREDYLQLLNQEQ
HGMLYARKPDNNLVRTYSTQAFVLSCKAATFGMLQALMKSIYEIPRLEGI
STEIKVTEVGGLRDYDVALIGSSGQPGCILLYGGCKDTNTLDVPNHVTVI
RFNVLYHGLEALKETLVGALPKITKIRVTAEAECLQVFRASQAGKSGNAG
GMRVTKGTIIAAHLTFRVCRKAPGHRVVVYEGQIKELRRFKELVPSVELG
LECGVIMQDEFQFRTGDILQQYETYEEPRDVAEEYQKAELREKIMRDTAA
AEAL
Ligand information
Ligand IDGDP
InChIInChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyQGWNDRXFNXRZMB-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.385NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
FormulaC10 H15 N5 O11 P2
NameGUANOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL384759
DrugBankDB04315
ZINCZINC000008215481
PDB chain7pua Chain IA Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7pua Mitoribosomal small subunit maturation involves formation of initiation-like complexes.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		V212 D213 H214 G215 K216 T217 T218 K312 D314 R348
Binding residue
(residue number reindexed from 1)		V173 D174 H175 G176 K177 T178 T179 K273 D275 R309
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003743 translation initiation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7pua, PDBe:7pua, PDBj:7pua
PDBsum7pua
PubMed35042777
UniProtC9ZSN7

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