Structure of PDB 8dh5 Chain I Binding Site BS03

Receptor Information
>8dh5 Chain I (length=837) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTINIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARF
RKMFERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPT
AFQFLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARF
GRIRDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAW
SSWHKEDSIHVGVRCIEMLIESTGMVSLHSETIELAPEYAEAIATRAGAL
AGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDV
YMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPKRAAAAVY
RKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQ
GNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEEN
HENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLA
FDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQAD
AINGTDNEVVTVTDENTGEISEKVKLGTKALAGQWLAYGVTRSVTKRSVM
TLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESV
SVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPV
WQEYKKPIQTRLNLMFLGQDSEIDAHKQESGIAPNFVHSQDGSHLRKTVV
WAHEKYGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFY
DQFADQLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh5 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		E643 R647 G675 K679 K704
Binding residue
(residue number reindexed from 1)		E608 R612 G640 K644 K669
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh5, PDBe:8dh5, PDBj:8dh5
PDBsum8dh5
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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