Structure of PDB 8dh3 Chain I Binding Site BS03

Receptor Information
>8dh3 Chain I (length=831) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NIAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKM
FERQLKAGEVADNAAAKPLITTLLPKMIARINDWFEEVKAKRGKRPTAFQ
FLQEIKPEAVAYITIKTTLACLTSADNTTVQAVASAIGRAIEDEARFGRI
RDLEAKHFKKNVEEQLNKRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSW
HKEDSIHVGVRCIEMLIESTGMVSLHRQNAGVVGQDSETIELAPEYAEAI
ATRAGALAGISPMFQPCVVPPKPWTGITGGGYWANGRRPLALVRTHSKKA
LMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVITKWKHCPVEDIPA
IWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMDWRGR
VYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVDKVPF
PERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGVQHHG
LSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIYGIVA
KKVNEILQADAINGTDNLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKE
FGFRQQVLEDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAV
EAMNWLKSAAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPI
QTRLNLMFLGQFRDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEKY
GIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFADQ
LHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB8dh3 Structural basis of transcription recognition of a hydrophobic unnatural base pair by T7 RNA polymerase.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		E643 R647 G675 K679 K700 K704
Binding residue
(residue number reindexed from 1)		E600 R604 G632 K636 K657 K661
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8dh3, PDBe:8dh3, PDBj:8dh3
PDBsum8dh3
PubMed36635281
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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