Structure of PDB 6ztr Chain I Binding Site BS03

Receptor Information
>6ztr Chain I (length=214) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
WVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVF
AVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIVTDQ
NDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIH
SQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDGDGS
TTTAVAVVEILDAN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ztr Chain I Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ztr PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E118 D174 E176 D210
Binding residue
(residue number reindexed from 1)		E10 D66 E68 D102
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ztr, PDBe:6ztr, PDBj:6ztr
PDBsum6ztr
PubMed33879555
UniProtP22223|CADH3_HUMAN Cadherin-3 (Gene Name=CDH3)

[Back to BioLiP]