Structure of PDB 6ztb Chain I Binding Site BS03

Receptor Information
>6ztb Chain I (length=217) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPE
GVFAVEKETGWLLLNKPLDREEIAKYELFGHAVSENGASVEDPMNISIIV
TDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAY
SIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQATDMDG
DGSTTTAVAVVEILDAN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ztb Chain I Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ztb PCA062, a P-cadherin Targeting Antibody-Drug Conjugate, Displays Potent Antitumor Activity Against P-cadherin-expressing Malignancies.
Resolution1.4 Å
Binding residue
(original residue number in PDB)		E118 E176 D207 Q208 D210 D243
Binding residue
(residue number reindexed from 1)		E13 E71 D102 Q103 D105 D138
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ztb, PDBe:6ztb, PDBj:6ztb
PDBsum6ztb
PubMed33879555
UniProtP22223|CADH3_HUMAN Cadherin-3 (Gene Name=CDH3)

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