Structure of PDB 6rwl Chain I Binding Site BS03

Receptor Information
>6rwl Chain I (length=270) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GFLDGIEKAQEEHEKYHNNWRAMAEDFQIPQVVAKEIVAQCPKCQVKGEA
MHGQVDASPKTWQMDCTHLEGKVIIVAVHVASGYIEAEVLPAETGKETAH
FLLKLAARWPVKHLHTDNGDNFTSSAVQAVCWWAQIEHTFGVPYNPQSQG
VVESMNHQLKTIITQIRDQAEKIETAVQMAVLIHNFKRKGGIGGYSAGER
IIDIIASDLQTTKLQNQISKIQNFRVYFREGRDQQWKGPATLIWKGEGAV
VIQDGQDLKVVPRRKCKIIK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6rwl Structural basis of second-generation HIV integrase inhibitor action and viral resistance.
Resolution3.36 Å
Binding residue
(original residue number in PDB)		G52 Q53 V54 V141 Q146 S147 G149 S153 M154
Binding residue
(residue number reindexed from 1)		G53 Q54 V55 V142 Q147 S148 G150 S154 M155
Enzymatic activity
Enzyme Commision number 3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:6rwl, PDBe:6rwl, PDBj:6rwl
PDBsum6rwl
PubMed32001525
UniProtE1ANT8

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