Structure of PDB 4xln Chain I Binding Site BS03

Receptor Information
>4xln Chain I (length=1112) Species: 271 (Thermus aquaticus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EIKRFGRIREVIPLPPLTEIQVESYKKALQADVPPEKRENVGIQAAFKET
FPIEEGGLVLDFLEYRIGDPPFSQDECREKDLTYQAPLYARLQLIHKDTG
LIKEDEVFLGHLPLMTEDGSFIINGADRVIVSQIHRSPGVYFTPDPARPG
RYIASIIPLPKRGPWIDLEVEASGVVTMKVNKRKFPLVLLLRVLGYDQET
LVRELSAYGDLVQGLLDEAVLAMRPEEAMVRLFTLLRPGDPPKKDKALAY
LFGLLADPKRYDLGEAGRYKAEEKLGVGLSGRTLVRFEDGEFKDEVFLPT
LRYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMADQFRVGLARLARGVR
ERMVMGSPDTLTPAKLVNSRPLEAALREFFSRSQLSQFKDETNPLSSLRH
KRRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLA
AYARVDALGFIRTPYRRVKNGVVTEEVVYMTASEEDRYTIAQANTPLEGD
RIATDRVVARRRGEPVIVAPEEVEFMDVSPKQVFSLNTNLIPFLEHDDAN
RALMGSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVVKV
DGTRIAVRYEDGRLVEHPLRRYARSNQGTAFDQRPRVRVGQRVKKGDLLA
DGPASEEGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTSIHIE
RYEIEARDTKLGPERITRDIPHLSEAALRDLDEEGIVRIGAEVKPGDILV
GRTSFKGEQEPSPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVGRLRL
RRGDPGVELKPGVREVVRVFVAQKRKLQVGDKLANRHGNKGVVAKILPVE
DMPHLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQRYISPVF
DGATEPEIKELLAEAFNLYFGKRQGEGFGVDKREKEVLARAEKLGLVSPG
KSPEEQLKELFDLGKVVLYDGRTGEPFEGPIVVGQMFIMKLYHMVEDKMH
ARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTIK
SDDIEGRNAAYQAIIKGEDVPEPSVPESFRVLVKELQALALDVQTLDEKD
NPVDIFEGLASK
Ligand information
Receptor-Ligand Complex Structure
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PDB4xln Structure of a bacterial RNA polymerase holoenzyme open promoter complex.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		L413 R420 P444 I452 Q567 K838 K846
Binding residue
(residue number reindexed from 1)		L407 R414 P438 I446 Q561 K832 K840
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4xln, PDBe:4xln, PDBj:4xln
PDBsum4xln
PubMed26349032
UniProtQ9KWU7|RPOB_THEAQ DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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