Structure of PDB 1ywh Chain I Binding Site BS03

Receptor Information
>1ywh Chain I (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEK
TNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVYLECISCGSSDMSCE
RGRHQSLQCRSPEEQCLDVVTHWIQRPKDDRHLRGCGYLPGCPGSNGFHN
NDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGQSTHGCSSEETF
LIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHI
DVSCCTKSGCNHPD
Ligand information
Ligand IDFUC
InChIInChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3+,4+,5-,6+/m0/s1
InChIKeySHZGCJCMOBCMKK-SXUWKVJYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@@H]1O[C@@H](O)[C@@H](O)[C@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)C
OpenEye OEToolkits 1.5.0CC1C(C(C(C(O1)O)O)O)O
OpenEye OEToolkits 1.5.0C[C@H]1[C@H]([C@H]([C@@H]([C@@H](O1)O)O)O)O
CACTVS 3.341C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
FormulaC6 H12 O5
Namealpha-L-fucopyranose;
alpha-L-fucose;
6-deoxy-alpha-L-galactopyranose;
L-fucose;
fucose
ChEMBLCHEMBL1232862
DrugBankDB04473
ZINCZINC000001532814
PDB chain1ywh Chain Y Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB1ywh Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide
Resolution2.7 Å
Binding residue
(original residue number in PDB)		R83 S117 E119
Binding residue
(residue number reindexed from 1)		R83 S111 E113
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0030377 urokinase plasminogen activator receptor activity
GO:0038023 signaling receptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0010755 regulation of plasminogen activation
GO:0030155 regulation of cell adhesion
GO:0030162 regulation of proteolysis
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0038195 urokinase plasminogen activator signaling pathway
GO:0043066 negative regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0051917 regulation of fibrinolysis
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0070161 anchoring junction
GO:0098552 side of membrane
GO:0098637 protein complex involved in cell-matrix adhesion
GO:1905370 serine-type endopeptidase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1ywh, PDBe:1ywh, PDBj:1ywh
PDBsum1ywh
PubMed15861141
UniProtQ03405|UPAR_HUMAN Urokinase plasminogen activator surface receptor (Gene Name=PLAUR)

[Back to BioLiP]