Structure of PDB 8g3o Chain H Binding Site BS03

Receptor Information

>8g3o Chain H (length=388) Species: 11320 (Influenza A virus)

AEYRNWSKPQCGITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDLDKCYQ
FALGQGTTLNNVHSNNTVRDRTPYRTLLMNELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCITGDDKNATASFIYNGRLVDSVVSWSNDILRTQESECV
CINGTCTVVMTDGNATGKADTKILFIEEGKIVHTSKLSGSAQHVEECSCY
PRYPGVRCVCRDNWKGSNRPIIDINIKDHSIVSSYVCSGLVGDTPRKSDS
SSSSHCLNPNNEEGGHGVKGWAFDDGNDVWMGRTINETSRLGYETFKVVE
GWSNPKSKLQINRQVIVDRGDRSGYSGIFSVEGKSCINRCFYVELIRGRK
EETEVLWTSNSIVVFCGTSGTYGTGSWPDGADLNLMHT

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 8g3o Chain H Residue 2000

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8g3o A pan-influenza antibody inhibiting neuraminidase via receptor mimicry.
• Resolution: 3.1 Å
• Binding residue (original residue number in PDB): D293 G297 D324 G345 G346 H347
• Binding residue (residue number reindexed from 1): D212 G216 D243 G264 G265 H266
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:8g3o, PDBe:8g3o, PDBj:8g3o
• PDBsum: 8g3o
• PubMed: 37258672
• UniProt: A0A5P8ETS7