Structure of PDB 7zkm Chain H Binding Site BS03

Receptor Information
>7zkm Chain H (length=250) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKEQPSV
LQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPF
VMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7zkm A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Y89 P92 R93 N95 W96 R97 W237 K240 Q244
Binding residue
(residue number reindexed from 1)		Y85 P88 R89 N91 W92 R93 W240 K243 Q247
Enzymatic activity
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:7zkm, PDBe:7zkm, PDBj:7zkm
PDBsum7zkm
PubMed36457701
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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