Structure of PDB 7yiw Chain H Binding Site BS03

Receptor Information
>7yiw Chain H (length=484) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTV
TAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAY
LCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTT
RVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDV
IMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSH
FIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAI
QILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTS
SEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGN
GPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPM
AHLLHGVHEQNYVPHVMAYAACIGANLGHCAPAA
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain7yiw Chain H Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7yiw The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
Resolution2.89 Å
Binding residue
(original residue number in PDB)		E235 F290 E291 T305 D306
Binding residue
(residue number reindexed from 1)		E218 F273 E274 T288 D289
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
3.9.1.1: phosphoamidase.
Gene Ontology
Molecular Function
GO:0004035 alkaline phosphatase activity
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005509 calcium ion binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0016887 ATP hydrolysis activity
GO:0033883 pyridoxal phosphatase activity
GO:0043262 ADP phosphatase activity
GO:0046872 metal ion binding
GO:0050187 phosphoamidase activity
GO:0052732 phosphoethanolamine phosphatase activity
Biological Process
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0003006 developmental process involved in reproduction
GO:0014070 response to organic cyclic compound
GO:0019725 cellular homeostasis
GO:0030282 bone mineralization
GO:0031214 biomineral tissue development
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0033280 response to vitamin D
GO:0034516 response to vitamin B6
GO:0036005 response to macrophage colony-stimulating factor
GO:0042822 pyridoxal phosphate metabolic process
GO:0046677 response to antibiotic
GO:0051384 response to glucocorticoid
GO:0055062 phosphate ion homeostasis
GO:0055074 calcium ion homeostasis
GO:0071407 cellular response to organic cyclic compound
GO:0071529 cementum mineralization
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140651 futile creatine cycle
GO:0140928 inhibition of non-skeletal tissue mineralization
GO:1904383 response to sodium phosphate
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0031966 mitochondrial membrane
GO:0065010 extracellular membrane-bounded organelle
GO:0070062 extracellular exosome
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yiw, PDBe:7yiw, PDBj:7yiw
PDBsum7yiw
PubMed37422472
UniProtP05186|PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme (Gene Name=ALPL)

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