Structure of PDB 7b5l Chain H Binding Site BS03

Receptor Information
>7b5l Chain H (length=423) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLME
RYFDGNLEKLFAECHVIMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYL
TTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSF
VECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVK
CKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQN
CKAEFCWVCLGPWEPHGSAWYNCNRSRAALQRYLFYCNRYMNHMQSLRFE
HKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAFY
LKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRY
CESRRRVLLQHVHEGYEKDLWEY
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7b5l Chain H Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7b5l Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		C276 C281 C297 C299
Binding residue
(residue number reindexed from 1)		C160 C165 C181 C183
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016740 transferase activity
GO:0019787 ubiquitin-like protein transferase activity
GO:0031624 ubiquitin conjugating enzyme binding
GO:0031625 ubiquitin protein ligase binding
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
GO:0039585 PKR/eIFalpha signaling
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016604 nuclear body
GO:0019005 SCF ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0097413 Lewy body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b5l, PDBe:7b5l, PDBj:7b5l
PDBsum7b5l
PubMed33536622
UniProtQ9Y4X5|ARI1_HUMAN E3 ubiquitin-protein ligase ARIH1 (Gene Name=ARIH1)

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